Don't start playing Abomination if you are expecting an original plotline of any kind. Abomination is chock full of stories from various science fiction and apocalyptic storylines thrown into one. A disease has begun spreading across the nation and has near destroyed all of humanity in North America. After infecting a particular human, the disease begins to profusely rip through the man or woman's skin and cause all sorts of mutations throughout them, barely making them recognizable as to what they used to be. Of the few that survived the chaos, some of them split off to form a cult called 'The Faithful' that would embrace this new outbreak as the next coming. The others - the ones who were fortunate enough to resist the cult and the new disease - formed a resistance to fight back against the cult, the disease, and simply fight for their lives.

Those who have formed the resistance can't do everything on their own, however. Thankfully, turns out the government had a back up plan in case something like this ever happened. Eight enhanced soldiers had been locked away in case of an emergency, and now that a time worthy of their use has come, they have been brought into action. These select eight are the ones who you will control in Abomination, and are the only ones who stand a chance at stopping the horde.

Abomination has taken the route of combining 3D character and enemy models with 2D environments for its graphics. This would work fine if the models for the characters had been worked on a bit more, since they look rather weak. It isn't very apparent from the screenshots of the game, but the models are pixely and are just plain ugly. Counteracting this, though, is the animation that moves fluidly and realistically. Different from other games in the genre, is that the environments that the action takes place in are incredibly interactive. Stuck trying to find an item hidden in the level? Whip out your shotgun and blast a few shells at a nearby car and watch it explode in a ball of napalm. There are other items littered across the area like dead bodies (some disturbing, such as a kid on a bike fallen on the ground with a pool of blood surrounding him) that can be inspected, mutations attached to poles, bushes and other places that can be blown up in a nice fashion.

A crucial element to any strategy game would be to have decent artificial intelligence so as to create the illusion that you are playing against something that is real, and thinking. There are apparent problems on both the sides of the characters that the player controls and 'The Faithful' cult wandering the streets. Your own characters, at times, will completely drift off from the group and go attack on their own. This poses the problem if he or she attacks a large group of enemies they stand no chance of winning against. If they do get into a fight with the enemy and you are able to drag them back to the main group, don't be surprised if the enemy follows suit and begins attacking you, resulting in you being unprepared and being easily dispatched of.

In the enemy's case, it is just the simple fact that the artificial intelligence is boring and relatively dumb. Sure, maybe 'The Faithful' are a group of mindless humans in a meaningless cult, but that doesn't mean they have to behave in a total zombie-like manner. Most of the human-type characters will walk around, limping from left to right and standing in the same spot while you blast away at them. Your characters, on the other hand, are dodging, rolling, etc. However, the enemy does come in large numbers, which balances out the idiotic AI for the most part.